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To carry out the meta-analysis on the clinical safety of glycyrrhizic acid and the influencing factors between 18 -glycyrrhizinate (18 -GL) and 18 -glycyrrhizinate (18 -GL). Magnesium isoglycyrrhizinate injection was used as the representative preparation of 18 -GL, and compound glycyrrhizin injection was used as the representative preparation of 18 -GL. The clinical control trial of magnesium isoglycyrrhizinate injection and compound glycyrrhizin injection was searched in a computer, which was published from January 2006 to December 201