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In summary, these finding suggest that cytochrome P450 metabolism plays a critical role in the low temperature resistance mechanism of PWN. This article is protected by copyright. All rights reserved.We report the synthesis and evaluation of a class of selective multitarget agents for the inhibition of HDAC6, HDAC8, and HDAC10. The concept for this study grew out of a structural analysis of the two selective inhibitors Tubastatin A (HDAC6/1 and PCI-34051 (HDAC8), which we recognized share the same N-benzylindole c