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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can cause chronic underachievement and depression. This is especially evident when they don't achieve their goals in terms of personal and professional. Overlapping symptoms of the comorbidities of ADHD and depression can make it difficult to determine a precise diagnosis. Recognizing the symptoms is a good first step to getting treatment. 1. Feelings of inadequacy Untreated ADHD and co-