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ADHD Treatment For Adults - Stimulant Medication Stimulant medications like methylphenidate and dextroamphetamine are generally considered first-line therapy for adult ADHD. These drugs increase and balance neurotransmitters in the brain. Antidepressants and nonstimulant medications like atomoxetine may be prescribed when stimulants are not suitable for the patient due to other health issues or adverse effects. These medications are slower acting than stimulants and reduce the impul