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This is certainly specially worrisome if you have a need to start out immunosuppressive therapies, since there is a risk of reactivation in undiscovered patients. We present an incident of feminine patient who was simply referred to the consultation because she was going to start chemotherapy with an anti-CD20 agent together with an optimistic anti-HBc and anti-HBs. During routine workup an occult hepatitis B virus illness was identified. Upon additional research mutations in the PreCore and