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But, the results and procedure underlying the immune reactions of teleost HKLs induced by nigericin continue to be enigmatic. To decipher the mechanism after nigericin treatment, the transcriptomic profile of goldfish HKLs was reviewed. The outcome demonstrated that a total of 465 differently expressed genetics (DEGs) with 275 up-regulated and 190 down-regulated genetics had been identified involving the control and nigericin treated groups. Included in this, the most truly effective 20 DEG K