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How to Choose the Best ADHD Medication for Adults Stimulant medicines like methylphenidate or amphetamine work by boosting and balancing brain chemicals. Doctors prescribe them as pills, liquids or patches. ADHD can be treated by healthcare professionals using medications called alpha-2 agonists as well as norepinephrine reup inhibitors. These medications are usually used "off-label", since they are FDA-approved for a variety of conditi