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The findings of this study may provide some insight into the pathogenesis of BRONJ development following implant placement in patients treated with zoledronate and may have promising implications toward improved wound healing and osseointegration in patients treated with alendronate. This study aimed to evaluate the effect of different surgical guide manufacturing techniques on the accuracy of the surgical guides produced prior to implant placement. Three type of guides were compared milled guides using a commercial milling unit (C-Mill)