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Medication For ADHD - What Are the Side Effects? Many people suffering from ADHD have their symptoms improved by taking medication. But each person reacts differently to different medications, and adverse reactions can be problematic. Methylphenidate is part of a class of drugs referred to as stimulants. It works by increasing levels of a substance in the brain that assists in controlling attention and behavior. Stimulant medication Stimulant drugs enhance concentration and attention in 70 to 80% of