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Therefore, the aim of our study would be to establish a body weight-directed infection trial model for glucose homeostasis. To that end, we conducted a model-based meta-analysis using time course information of bodyweight loss (after life style modification or surgical procedure) and corresponding enhancement of insulin sensitiveness expressed since the Matsuda index. Alterations in bodyweight were most readily useful explained by a sigmoidal Emax design, whereas changes in the Matsuda index had been bes