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Copyright © 2020 American Chemical Society.Nanoparticle (NP)-stabilized foam technology has found potential applications in CO2 enhanced oil recovery (EOR) and greenhouse gas geological storage practices and accordingly attracts lots of research interest. To screen the optimal formula for the satisfactory foam performance, orthogonal experimental design (OED) is used in this paper for the complex multifactor multilevel system consisting of five influential factors of NP size, surfactant concentration, NP concentration, temperature, and