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What Happens If ADHD is Left Untreated in Adults? Untreated ADHD can lead to a myriad of problems for adults. These problems can affect relationships, work, and mental health. Adults who suffer from untreated ADHD often have low self-esteem and have a negative outlook on the world. This can make them feel like they are failing at work and at home. Lack of Focus It is normal to have trouble focusing from time-to-time, especially after a busy day at school or work. I