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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can lead to chronic underachievement and depression. This is especially evident when they don't achieve their professional and personal goals. It can be difficult to make when there are overlaps in symptoms between ADHD and depression. Finding the signs is a good first step towards seeking treatment. 1. Feelings of inadequacy Untreated ADHD and co-occurring disorders of depression can cause feelings of feeling