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The H2L ligand and its complexes are excellent candidates for NLO materials as implied from their hyperpolarizabilities and polarizabilities values. The biological activities of the prepared complexes against selected microorganisms and cancer cell lines gave good growth inhibitory effect. The biocidal potencies of the ligand and its complexes can be arranged as follows AgL CuL PdL H2L, as compared to the used standard drugs. The antiproliferative activity of the studied complexes against different carcinoma cell lines such