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Temporal artery biopsy (TA is frequently still required in patients with suspected cranial giant cell arteritis (GCA). The literature on the performance characteristics of TAB versus imaging is conflicting, and several meta-analyses suggest that TAB is more sensitive than ultrasound. False-positive ultrasound results can occur. Also, diseases that mimic the symptoms, signs or imaging characteristics of GCA may only be revealed on pathology.Targeting the mu opioid receptor (MOR) by applying orthosteric ligands is the most frequently em