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Compounds that may attenuate activities of histones tend to be therefore of great interest, with heparin being one such material which has previously been proven to bind to histones. Heparin, a fruitful anticoagulant for almost a hundred years, has been confirmed experimentally to bind to histones and display a protective effect in inflammatory conditions. In the present study performed in entire bloodstream, heparin and selectively desulfated heparin paid down histone induced inflammatory marker