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359, 95% CI 1.377-4.040, =.002 and HR 1.791, 95% CI 1.176-2.729, =.007, respectively). But in the long-term, anorexia (HR 1.392, 95% CI 1.070-1.811, =.014) was the only symptom significantly associated with patient's all-cause mortality after adjusting for other confounding factors. Our study demonstrated that nausea and anorexia were the most important predialysis symptoms, which was associated with patients' short- and long-term mortality on PD treatment, respectively. The results indicated that predialysis evaluation and management of symptoms of