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Pathway analysis indicated that alterations in these metabolites had been associated with cysteine and methionine metabolism, citric acid period, glycolysis and glycolic regeneration, pyruvate metabolism, biosynthesis of valine, leucine and isoleucine, biosynthesis of primary bile acids, glycine, serine and threonine metabolic process, caffeinated drinks metabolism, arginine and proline metabolism and phenylalanine metabolism. It is really w