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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can lead to chronic underachievement and depression. This is especially the case when they fail to meet their personal and professional objectives. The overlap of symptoms from the comorbidities of ADHD and depression can make it challenging to get an accurate diagnosis. However, identifying the symptoms is the first step to finding treatment. 1. Feelings of Inadequacy Many peo