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Interaction with online workbooks was combined with navigation coaching delivered by phone and secure text messaging. In a two-level linear mixed-effects model intention-to-treat analysis, significant between-group differences were found for the Beck Depression Inventory-II score (difference -8.54, P=.01), Quick Inventory of Depressive Symptoms score (difference -4.94, P=.001), Beck Anxiety Inventory score (difference -11.29, P.001), and Brief Pain Inventory score (difference -1.99, P=.03), while marginal differences were found for