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This study analyzes the trend and spatial distribution of coronavirus disease 2019 (COVID-19) cases with geographic information systems approach from January 23, 2020, to January 1, 2021. The prevalence of COVID-19 on the tested population, the case fatality rate, and cured rate in Nepal was ~13.00%, ~0.71%, and ~96.97%, respectively. The prevalence (~1.87) and death rate (~1.28 times) were higher among men than women and ~68% of fatal cases were with comorbidities-distinctly hypertension and chronic kidney diseases. The distribution of C