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-based therapies. CONCLUSIONS This review paper will provide an overview of all technologies available in the area and inspect the current IoT applications in cell-based therapies to identify the benefits, challenges, and future directions of using IoT to allow safe and cost-effective delivery of cell-based therapies. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID) PRR1-10.2196/16935. ©Ching Lam, Michelle Helena van Velthoven, Edward Meinert. Originally published in JMIR Research Protocols (http//www.researchprotocols.org), 31.03.2020.