https://www.selleckchem.com/pr....oducts/as1517499.htm
Genes coding for CD11c (ITGAX), T-bet (TBX21), TACI (TNFRSF13, Src tyrosine kinases and NF-κB pathway-related genes were, among others, significantly upregulated in glandular FcRL4+ B cells versus FcRL4- B cells. Pathway analysis showed upregulation of B cell activation, cell cycle and metabolic pathways. Thus, FcRL4+ B cells in pSS exhibit many characteristics of chronically activated, pro-inflammatory B cells and their gene expression profile suggests increased risk of lymphomagenesis. We postulate that these cells contribute sign
Like
Comment
Share
