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miR-145-5p targeted FSCN1. HUCB-MSCs-derived exosomes alleviated pathological damages, enhanced liver function, reduced collagen accumulation and reduced α-SMA and collagen I expression, inhibited inflammation, apoptosis, caspase-3 and Bax expression, and increased Bcl-2 expression in HF. Restored miR-145-5p further strengthened the efficacy of HUCB-MSCs-derived exosomes in HF. This article makes it comprehensive that exosomes derived from miR-145-5p-modified HUCB-MSCs attenuate HF via down-regulating FSCN1 expression, widening our hori