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menopausal middle-aged women, CHIP was independently associated with incident coronary artery disease (hazard ratio associated with all CHIP 1.36 [95% CI, 1.07-1.73]; =0.012; hazard ratio associated with CHIP with variant allele frequency 0.1 1.48 [95% CI, 1.13-1.94]; =0.005). Premature menopause, especially natural premature menopause, is independently associated with CHIP among postmenopausal women. Natural premature menopause may serve as a risk signal for predilection to develop CHIP and CHIP-associated cardiovascular disease. Pr