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To analyze the spatial pattern of AIDS mortality and social factors associated with its occurrence. An ecological study that considered 955 AIDS deaths of residents in Piauí, reported in the Mortality Information System (MIS) from 2007 to 2015. Non-spatial and spatial regression models were used to identify social determinants of AIDS mortality, with a significance of 5%. The predictors of AIDS mortality were illiteracy rate in males (p = 0.02, proportion of households with water supply (p = 0.015), percentage of peopl