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In addition, treatment with cGMP significantly enhanced Ryr2 expression in cultured photoreceptor-derived Weri-Rb1 cells. Findings from this work demonstrate the regulation of cGMP/PKG signaling on RyR2 in the retina and support the role of RyR2 upregulation in cGMP/PKG signaling-induced ER stress and photoreceptor degeneration. © 2020 Federation of American Societies for Experimental Biology.Chirality is becoming increasingly important in the design of organic materials with functional properties, when bulk anisotropy is needed. In the
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