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Comparison between disease severity observed by inspectors and the disease burden assessed by patients is scanty in acne study. In a multicenter prospective hospital-based study, modified Comprehensive Acne Severity Scale (mCASS) and Cardiff Acne Disability Index (CADI) were employed to grade disease severity and to determine the quality of life, respectively. The average of the mCASS and CADI scores, with range at 0-25, was termed as Acne Severity and Impact Grading System (ASIG). In 1331 evaluated patients (mean 21,51±4,93 years), inc