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g., increasing the BOD5COD ratio from 0.11 to 0.42. A synergistic combination of Fenton oxidation process with the BAF reactor offered desirable mineralization efficiencies of EfOM (70%) at lower dosages of Fenton's reagents. The present results suggest that Fenton oxidation process combining with the BAF reactor can be a promising strategy for the advanced treatment of EfOM in IPWTP secondary effluents. This study provides guidance for the characterization and advanced treatment of EfOM in IPWTP secondary effluents for practical purpose.Antibiotic resi