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BACKGROUND The role of -251AT polymorphism in the anti-inflammatory cytokine interleukin-8 (IL-8) gene in gastric cancer was intensively evaluated, but the results of these studies were inconsistent. OBJECTIVE Therefore, we performed a meta-analysis to provide a comprehensive data on the association of IL-8 -251TA polymorphism with gastric cancer. METHODS All eligible studies were identified in PubMed, Web of Science, EMBASE, Wanfang and CNKI databases before September 01, 2019. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were d