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To examine the association of long-term weight change with rheumatoid arthritis (RA) risk in a large prospective cohort study. The Nurses' Health Study (NHS) II started in 1989 (baseline); after exclusions, we studied 108,505 women 25-42 years old without RA. Incident RA was reported by participant and confirmed by medical record review. Body weight was reported biennially through 2015. We investigated two time-varying exposures weight changes from baseline and from age 18; change was divided into 5 categories. We used a marginal struct