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r genomic modifications. Extra scientific studies, additionally into the framework of PARP inhibitors, are warranted. Copyright ©2020, American Association for Cancer Research.There is a need to produce book techniques to boost the balance between efficacy and toxicity for transcription aspect focused therapies. In this research, we exploit context dependent differences in RNAPII processivity as an approach to boost the game and limit the toxicity regarding the EWS-FLI1 targeted small mol