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GABPB1-AS1 expression in HPV16-positive CC tissues had been absolutely connected with cyst dimensions, lymph node metastasis, and FIGO phase. High phrase of GABPB1-AS1 ended up being correlated with an unhealthy prognosis for HPV16-positive CC patients. Functionally, E6-induced GABPB1-AS1 overexpression facilitated CC cells expansion and intrusion in vitro plus in vivo. Mechanistically, GABPB1-AS1 acted as a competing endogenous RNA (ceRNA) by sponging miR-519e-5p, causing the de-repression of the target gene Not