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There are limited data on acute injury-related medical encounters (injuries) in endurance cycling events. To determine the risk factors for injuries during a mass community-based endurance cycling event. Retrospective, cross-sectional study. Cape Town Cycle Tour (109 km), South Africa. 102 251 race starters. All injuries for 3 years were recorded by race medical doctors and nurses. Injuries were grouped into main anatomical area of injury, and a Poisson regression model was used to determine the risk factors associated with injuries. The