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Background Arm choice for peripherally inserted central catheter (PICC) insertion is often determined by PICC nurses.Objectives To explore the impact of arm choice (dominant or non-dominant) on the rate of catheter-related complications and degree of comfort in patients with PICCs.Design A cross-sectional study.Methods We used questionnaires and scales to collect 255 patients' general information, catheter-related complications and comfort degree. They were divided into two groups (PICC inserted in the dominant or non-dominant arm).Re