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It was also marked by changes in activated T cells populations including a reduction of CD45RO peripheral memory T cells from 80 % to 30 % and an increase (up to 70 %) in CD45RA effector T cells. Significantly higher levels of MMP9, VEGF-A and cathepsin G were also associated with advancing of wounds to poorly healing state. Our data demonstrated that wound-covering bandages are useful for a non-invasive sampling and analysis of wound-associated constituents and that transition to poorly healing wounds in RDEB patients as associated wi
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