https://perifosineinhibitor.co....m/compound-signals-d
Useful assays revealed that SMAD6 downregulation presented the formation of endothelial mobile tubes with lacking cell-cell junctions and facilitated the purchase of mesenchymal behavior by endothelial cells. Masson trichrome and immunofluorescence staining demonstrated that mesenchymal phenotype of endothelial cells is promoted in microhemorrhagic bAVMs. Conclusions TGFβ/BMP signaling mediated by SMAD6 in vascular endothelial cells is involving microhemorrhagic bAVMs, and mesenchymal behavior
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