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Electro-Fenton (EF) is an emerging technology with well-known outstanding oxidation power; yet, its application to the treatment of inorganic contaminants has been largely disregarded. Thiosalts are contaminants of emerging concern in mine water, responsible for delayed acidity in natural waterways. In this study, EF was used to treat thiosalts in synthetic and real mine water. Thiosulfate (S2O32-) solutions were first used to optimize the main parameters affecting the process, namely, the current density (2.08-6.25 mA cm-2), temperature