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How Does ADHD Medication Work? When one neuron sends a signal to another, it utilizes neurotransmitters or chemicals. These chemicals must travel through a small gap that is called a synapse. Some ADHD medications make the transmission of these messages more efficient. They either assist neurons in the release of more neurotransmitters or slow down the reuptake process (called reuptake inhibitors). Doctors begin ADHD patients on a low dosage and monitor their response. They gradually adj