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We tested if we could replicate the main effect relations of elevated striatum and lateral orbitofrontal cortex (OFC) response to high-calorie food stimuli to weight gain reported in past papers in six prospective datasets that used similar fMRI paradigms. Participants in Study 1 (N = 37; M age = 15.5), Study 2 (N = 160; M age = 15.3), Study 3 (N = 130; M age = 15., Study 4 (N = 175; M age = 14.3), Study 5 (N = 45; M age = 20.8), and Study 6 (N = 49; M age = 31.1) completed fMRI scans at baseline and had their BMI and body fat (Studi
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