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6 × 105 NPs/ml. Examined water sources, milk and milk products were potential reservoirs for virulent antibiotic-resistant E.coli which may impose animal and public health threats.Abbreviations APEC Avian pathogenic E. coli; blaCTX-M β-lactamase inhibitors-Cefotaximase gene; blaTEM β-lactamase inhibitors-Temoneira gene; CFU Colony-forming unit; DAEC Diffusely adherent E. coli; DEC Diarrheagenic Escherichia coli; DEMSO Dimethyl sulfoxide; eaeA Intimin or E. coli attaching gene; EAEC Enteroaggregative E. coli; EHEC Enterohemorrhagic E. col