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002). ERCP and CT imaging were more commonly utilized in US compared to non-US (p less then 0.0001), but there were no differences in the use of MRI/MRCP. Disease burden was highest in the West and Midwest, possibly because total pancreatectomy and islet autotransplantation (TPIAT) referral sites were located in these regions. All therapies were less commonly administered in non-US sites (p less then 0.0001). CONCLUSION This is the first study to describe geographical variations in the INSPPIRE cohort, which possibly reflect variati