https://frax486inhibitor.com/c....omparative-impact-in
Nonetheless, the method by which these oncometabolites inhibit HDR continues to be defectively grasped. Right here we determine the path by which these metabolites disrupt DNA repair. We show that oncometabolite-induced inhibition associated with the lysine demethylase KDM4B results in aberrant hypermethylation of histone 3 lysine 9 (H3K9) at loci surrounding DNA breaks, masking a local H3K9 trimethylation sign that is essential for the appropriate execution of HDR. Conse
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