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To assess the association of CYP2C19 and CYP3A5 gene polymorphisms with the risk of myocardial infarction. Five hundred patients with myocardial infarction and 500 healthy controls were randomly selected. Fluorescent PCR and Sanger sequencing were used to detect the CYP2C19 and CYP3A5 gene polymorphisms. Logistic regression was used to analyze the correlation between the polymorphisms and myocardial infarction. Quanto software was used to evaluate the statistical power. The two groups had significant difference in the frequency of AG, GG genot