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In accordance with transfection the RPMI8226 cells had been dividide into RPMI 8226 (untreated RPMI 8226), RPMI 8226 /shRNA-Met and RPMI8226/shRNA-control team, respectively. Protein expression standard of c-Met was detected by Western blot so as to evaluate transfection problem; the proliferation associated with the cells ended up being detected by MTT; apoptosis and period regarding the cells were detected by movement cytometry; effect of c-Met/shRNA on RPMI 8226 mobile adhesion was