https://www.selleckchem.com/pr....oducts/pifithrin-u.h
To develop a new nanoparticle formulation for a proteasome inhibitor Carfilzomib (CFZ) to improve its stability and efficacy for future in vivo applications. CFZ-loaded ternary polypeptide nanoparticles (CFZ/tPNPs) were prepared by using heptakis(6-amino-6-deoxy)-β-cyclodextrin(hepta-hydrochloride) (HaβCD) and azido-poly(ethylene glycol)-block-poly(L-glutamic acid sodium salt) (N -PEG-PLE). The process involved ternary (hydrophobic/ionic/supramolecular) interactions in three steps 1) CFZ was entrapped in the cavity of HaβCD by hydro
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