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1%) patients in the transradial group versus 22 (81.5%) in the transfemoral group (adjusted hazard ratio [HR] 0.49, 95% confidence interval [CI] 0.28-0.84; P=0.012). The transradial approach was associated with reduced rates of death/MI/stroke (adjusted HR 0.53, 95%CI 0.31-0.91; P=0.02) and major bleeding (adjusted HR 0.34, 95%CI 0.13-0.87; P=0.02). The meta-analysis confirmed the benefit of transradial access in terms of mortality (relative risk [RR] 0.63, 95%CI 0.58-0.68) and major bleeding (RR 0.43, 95%CI 0.32-0.59). The