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ADHD Medications For Adults Stimulants can help regulate levels of chemical messengers that control the brain's attention. They are considered to be the first-line medication in the treatment of ADHD. Although they are not habit-forming, they can cause side effects such as headaches and difficulty sleeping. Your doctor may prescribe Guanfacine (brand names Tenex and Intuniv) or clonidine (Catapres) to reduce hyperactivity and impulsivity. These medications have a