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h KRAS-mutant and wild-type CRC. Despite its beneficialproperties,higheradiponectinconcentrations are paradoxically associated with mortality in advanced age. Several mechanisms are being discussed. However, little is known about postprandial regulation of adiponectin in older adults. We assessed age-specific differences of the adiponectin response to different test meals considering potential determinants. Older(n=2andyounger(n=22)womenare randomizedtoadextrose(DEX)orhigh-fat(HF)dietarychallenge. Postprandial adiponectin and fibrobla