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abetes undergoing major surgery. Trial registration Clinicaltrials.gov identifier NCT01790529. Obesity is considered a condition of systemic chronic inflammation. Under this condition, adipose tissue macrophages switch from an M2 (anti-inflammatory) activation pattern to an M1 (proinflammatory) activation pattern. The study aimed to verify the profile of skin macrophage activation after bariatric surgery as well as the role of MMP-1 in extracellular tissue remodeling. This is a prospective, controlled and comparative study with 20 indivi